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KMID : 0380420100340030189
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Journal of Prventive Veterinary Medicine
2010 Volume.34 No. 3 p.189 ~ p.195
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Original Article : Detection of galE gene in Campylobacter spp. associated with Guillain-Barre syndrome using polymerase chain reaction
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Ku Bok-Kyung
Kim Hae-Ji
Kim Young-Il
Choi Jung-Soo
Park Mi-Young
Kwon Jin-Wook
Kim Yong-Hwan
Kim Jong-Hyun
Lee Young-Ju
Kim Eun-Gyeong
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Abstract
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Guillain-Barre syndrome (GBS) is the most common cause of acute flaccid paralysis and autoimmune polyradiculoneuropathy. Campylobacter jejuni is the most commonly identified infectious trigger for GBS. A sialic-acid containing lipopolysaccharide (LPS) of Campylobacter is thought to be involved in the triggering of GBS. The galE (UDPgalactoset- epimerase) gene of Campylobacter spp. is involved in the synthesis of LPS. In this study, we detected the galE gene in Campylobacter spp. responsible for triggering the onset of GBS. The PCR assay detected the presence
of the gene in 14 of the 25 (56%) Campylobacter isolates from domestic chicken, 20 of the 28 (71.4%) Campylobacter
isolates from imported chicken and 50 of the 51 (98%) Campylobacter isolates from human clinical samples. Also, the
specific 497-bp region of galE sequence in Campylobacters responsible for triggering the onset of GBS was amplified
from GBS patient. These results could provide evidence of the first GBS-related C. jejuni infection in Korea.
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KEYWORD
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Campylobacter, GBS, galE Gene
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